F A C U L T Y P R O F I L E
GHEZ, CLAUDE P.J., M.D.
Neural control of multi-joint limb movement in the cat and in humans.
Office: PI Annex| 8th floor | Room 822
Our work investigates the sensory mechanisms involved in the learning and control of reaching movements in normal human subjects and in normal human subjects and in patients with neurological disturbances. Current studies are informed by our earlier findings that (1) even simple reaching movements involve separate control actions responsible for trajectory formation and stabilized final positions; and (2) that visual and proprioceptive sensory signals play different roles in ongoing feedback control and motor learning. Our current research focuses on two general questions. First, we are studying how interactions of motor and sensory impairments in hemiparesis due to stroke produce specific impairments in the learning and control of trajectory and stabilization of limb position. These studies use robotic manipulanda and novel paradigms to experimentally manipulate biomechanical demands and impedance control to dissect the underlying neural control of posture and movement in stroke survivors. Second, we have recently shown that normal human subjects can use auditory feedback of kinematic variables (i.e. “auditory kinesthesia”) to correct reaching errors and to learn new visuomotor transformations in the absence of explicit visual cues. We are now studying the use of simple sonic information as well as musical material itself as a framework for encoding the rich multidimensional information constituting posture and movement.
Deficits of sensorimotor control and their impact on limb stabilization post-stroke.
Mrotek LA Stoeckmann T; Bengtson M; Ghez C; Scheidt RA Society for Neuroscience Abstracts 2013.
Ghez C and Faith A. Accuracy and adaptation to visuomotor gain changes in reaching and reversal movements using auditory feedback of distance and hand speed. Society for Neuroscience Abstracts 2013.
Simo L, Botzer L, Ghez C, Scheidt RA. Sensitivity, specificity and repeatability of an automated evaluation of proprioceptive integrity in the hemiparetic arm post-stroke submitted Neurorehabilitation and Neural Repair.
Gazes Y, Brian C Rakitin BC, Steffenera JC, Christian Habeck C, Brady Butterfield B, Ghez C, Stern Y (2010). Performance degradation and altered cerebral activation during dual performance: Evidence for a Bottom-up Attentional system Behav Brain Res 210:229-239.
Scheidt RA, Ghez C, Asnani S (2011) Patterns of hypermetria and terminal co-contraction during point-to-point movements demonstrate independent action of trajectory and postural controllers. J Neurophysiol. 106(5), 2368-2382.
Arce F, Itai Novick I, Mandelblat-Cerf Y, Israel Z, Ghez C, and Eilon Vaadia E. (2010). Combined Adaptiveness of Specific Motor Cortical Ensembles Underlies Learning J Neurosci, 30, 5415-5425.
Arce F, Novick I, Shahar M, Link Y, Ghez C, et al. (2009).Differences in Context and Feedback Result in Different Trajectories and Adaptation Strategies in Reaching. PLoS ONE 4(1): e4214.
Scheidt, R.A., and Ghez, C. 2007. Separate adaptive mechanisms for controlling trajectory and final position in reaching. J. Neurophysiol. 98:3600-3613.
Ghez, C., Scheidt, R., and Heijink, H. 2007. Different learned coordinate frames for planning trajectories and final positions in reaching. J. Neurophysiol. 98:3614-3626.
Habeck, C., Krakauer, J.W., Ghez, C., Sackeim, H.A., Eidelberg, D., Stern, Y., and Moeller, J.R. 2005. A new approach to spatial covariance modeling of functional brain imaging data: ordinal trend analysis. Neural Comput. 17:1602-45.
Krakauer, J.W., Ghez, C., and Ghilardi, M.F. 2005. Adaptation to visuomotor transformations: consolidation, interference, and forgetting. J Neurosci. 25:473-8.
Krakauer, J.W., Ghilardi, M.F., Mentis, M., Barnes, A., Veytsman, M., Eidelberg, and D., Ghez, C. 2004. Differential cortical and subcortical activations in learning rotations and gains for reaching: a PET study. J Neurophysiol. 91:924-33.
Ghilardi, M.F., Carbon, M., Silvestri, G., Dhawan, V., Tagliati, M., Bressman, S., Ghez, C., and Eidelberg, D. 2003. Impaired sequence learning in carriers of the DYT1 dystonia mutation. Ann Neurol. 54:102-9.
Mentis, M.J., Dhawan, V., Nakamura, T., Ghilardi, M.F., Feigin, A., Edwards, C., Ghez, C., and Eidelberg, D. 2003. Enhancement of brain activation during trial-and-error sequence learning in early PD. Neurology. 60:612-9.
Fukuda, M., Ghilardi, M.F., Carbon, M., Dhawan, V., Ma, Y., Feigin, A., Mentis, M.J., Ghez, C., and Eidelberg, D. 2002. Pallidal stimulation for parkinsonism: improved brain activation during sequence learning. Ann Neurol. 52:144-52.
Feigin, A., Ghilardi, M.F., Fukuda, M., Mentis, M.J., Dhawan, V., Barnes, A., Ghez, C.P., and Eidelberg, D. 2002. Effects of levodopa infusion on motor activation responses in Parkinson's disease. Neurology. 59:220-6.
Fukuda, M., Mentis, M., Ghilardi, M.F., Dhawan, V., Antonini, A., Hammerstad, J., Lozano, A.M., Lang, A., Lyons, K., Koller, W., Ghez, C., and Eidelberg, D. 2001. Functional correlates of pallidal stimulation for Parkinson's disease. Ann Neurol. 49:155-64. Nakamura T, Ghilardi MF, Mentis M, Dhawan V, Fukuda M, Hacking A, Moeller JR, Ghez C, Eidelberg D. (2001). Functional networks in motor sequence learning: abnormal topographies in Parkinson's disease. Hum Brain Mapp. 12:42-60.
Cooper, S.E., Martin, J.H., and Ghez, C. 2000. Effects of inactivation of the anterior interpositus nucleus on the kinematic and dynamic control of multijoint movement. J Neurophysiol. 84:1988-2000.
Ghilardi, M., Ghez, C., Dhawan, V., Moeller, J., Mentis, M., Nakamura, T., Antonini, A., and Eidelberg, D. 2000. Patterns of regional brain activation associated with different forms of motor learning. Brain Res. 871:127-45.
Martin, J.H., Cooper, S.E., Hacking, A., and Ghez, C. 2000. Differential effects of deep cerebellar nuclei inactivation on reaching and adaptive control. J Neurophysiol. 83:1886-99.
Ghez, C., Favilla, M., Ghilardi, M.F., Gordon, J., Bermejo, R., and Paullman, S. 1997. Discrete and continuous planning of hand movements and isometric force trajectories. Exp. Brain Research 115:217-233
Virji-Babul, N., Sainburg, R.L., Huang, H., and Ghez, C. 1997. Rate of learning novel limb dynamics depends on the nature of feedback signals. Soc. Neurosci. Abstract, 85.7:002
Krakauer, J.W., Pine, Z.M., Ghuilardi, M.F., Huang, H., and Ghez, C. 1997. Learning a rotated reference frame requires moving in multiple directions and differs with the joint system used. Soc. Neurosci. Abstract, 85.8:202
Pine, Z.M., Krakauer, J.W., Gordon, J., and Ghez, C. 1996. "Learning of scaling factors and reference axes for reaching movements". Neuroreport 7:2357-2361
Ghilard, M.F., Gordon, J., and Ghez, C. 1995. Learning a visuomotor transformation in a local area of workspace produces directional biases in other areas. J. Neurophysiol. 73.6:2535-2539