F A C U L T Y   P R O F I L E 

photon image

Professor of Physiology & Cellular Biophysics and Medicine

Endothelial mechanisms of lung injury using cultured cells and the optically imaged lung.

Office: Black Building| 8th Floor| Room 812
Telephone: 212.305.7093
Fax: 212.305.6701

Current Research

The Lung Biology Laboratory specializes in single and two-photon laser scanning microscopy of the intact lung. The overall direction is to apply real-time imaging in understanding molecular mechanisms underlying lung injury. Ongoing projects are:

• Mitochondrial regulation of lung immunity
• Immune interactions of alveolar macrophages in situ
• Lung mechanobiology of the actin fence
• Platelet-neutrophil interactions in immunity
• Protein transduction in therapy for lung injury

Selected Publications

Westphalen K, Gusarova G, Islam MN, Subramanian M, Cohen TS, Prince AS, J Bhattacharya. Sessile alveolar macrophages modulate immunity through connexin 43-based epithelial communication. Nature. 2014 Feb 27; 506(7489):503-506. PMID:24463523

Huang SXL, Islam MN, O’Neil J, Hu Z, Yang Y-G, Chen Y-W, Mumau M, Green MD, Vunjak-Novakovic G, Bhattacharya J, Snoeck H-W. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nature Biotechnology. Nat Biotechnol. 2014 Jan; 32(1):84-91. PMID: 24291815

Islam MN, Gusarova GA, Monma E, Das SR, Bhattacharya J. F-actin scaffold stabilizes lamellar bodies during surfactant secretion. Am. J. Physiol. Lung Cell Mol. Physiol. 2014 Jan 1; 306(1): L50-57. PMID:24213916

Looney MR, J Bhattacharya. Live imaging of the lung. Annu. Rev. Physiol. 2014 Feb 10; 76:431-445. PMID: 24245941

Rogers RS, J Bhattacharya. When cells become organelle donors. Physiology (Bethesda). 2013 Nov; 28(6):414-422. PMID:24186936

Huertas, A., Das, S., Emin M., Rifkind JM, J. Bhattacharya and S. Bhattacharya. Erythrocytes induce proinflammatory endothelial activation in hypoxia. Am J Respir Cell Mol Biol. 2013; 48:78-86. PMID:23043086

Bhattacharya J, Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013; 75:593-615. PMID: 23398155

Quadri S, Sun L, Islam MN, Shapiro L, Bhattacharya J. Cadherin selectivity filter regulates endothelial sieving properties. Nat Commun. 2012;3:1099. PMID:23033075.

Emin, Memet T, Li Sun, A Huertas, S Das, J Bhattacharya, S Bhattacharya. Platelets induce endothelial tissue factor expression in a mouse model of acid-induced lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 2012 Jun 1;302(11):L1209-20. PMID:22505671.

Kristin Westphalen, Eiji Monma, Mohammad N. Islam & Jahar Bhattacharya. Acid contact in the rodent pulmonary alveolus causes proinflammatory signaling by membrane pore formation. Am. J. Physiol. Lung Cell Mol. Physiol. 2012. 303:L107-16. PMID:22561462.

Islam MN, S Das, MT Emin, M Wei, L Sun, K Westphalen, D Rowlands, S Quadri, S Bhattacharya, J Bhattacharya. Mitochondrial transfer from bone marrow-derived mesenchymal stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012. 18:759-765. PMID:22504485.

Bhattacharya, J. 2012. Lung capillaries raise the hypoxia alarm. J Clin Invest. 2012 Nov 1;122(11):3845-7. PMID: 21191375.

Rowlands DJ, MN Islam, S Das, A Huertas, S Quadri, K Horiuchi, N. Inamdar, MT Emin, J Lindert, VS Ten, S Bhattacharya, J Bhattacharya. Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels. J. Clin. Invest. 2011. 121:1986-99. PMID: 21519143.

Perlman, CE, DJ Lederer and J. Bhattacharya. Micromechanics of alveolar edema. Am. J. Resp. Cell. Mol. Biol. 2011. 44:34-9. PMID: 20118224.

Bhattacharya, J. 2010. Seeing is believing. N&V Nature Meth. 8:57-58. PMID: 21191375.

Bhattacharya J, Perlman CE. Commentaries on Viewpoint: Standards for quantitative assessment of lung structure. Air space connectivity. J Appl Physiol. 2010. 109:935-6; PMID: 20848692.

Kiefmann, R., Rifkind, J.M., Nagababu, E., and Bhattacharya, J. 2008. RBC induce hypoxic lung inflammation. Blood. (In press)

Bhattacharya, J. 2008. Lung neovascularization: a tale of two circulations. Am J Physiol Lung Cell Mol Physiol. (Epub)

Quadri, S., and Bhattacharya, J. 2007. Resealing of endothelial junctions by focal adhesion kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 292:L334-42.

Lindert, J., Parthasarathi, K., and Bhattacharya, J. 2007. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am. J. Resp. Cell. Mol. Biol. 36:688-96.

Perlman, C.E., and Bhattacharya, J. 2007. Alveolar micromechanics determined by optical sectioning microscopy. J. Appl. Physiol. 103:1037-44.

Bertuglia, S., Ichimura, H., Fossati, G., Parthasarathi K., Leoni, F., Modena, D., Cremonesi, P., Bhattacharya, J., and Mascagni, P. 2007. ITF1697, a stable Lys-Pro–containing peptide, inhibits Weibel Palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 13:615-24.

Kuebler, W.M., Parthasarathi, K., Lindert, J., and Bhattacharya, J. 2007. Real-time lung microscopy. J Appl Physiol. 102:1255-64.

Bhattacharya, J. 2007. Interpreting the lung microvascular filtration coefficient. Am J Physiol Lung Cell Mol Physiol. 79:357-66

Chatterjee, S., Baeter, S., and Bhattacharya, J. 2007. Endothelial and epithelial signaling in the lung. Am J Physiol Lung Cell Mol Physiol, 293: L517-19.

Ichimura, H., Parthasarathi, K., Issekutz, AC., and Bhattacharya, J. 2005. Pressure-induced leukocyte margination in lung postcapillary venules. Am J Physiol Lung Cell Mol Physiol. 289:L407-12.

Safdar, Z., Yiming, M., Grunig, G., and Bhattacharya, J. 2005. Inhibition of Acid-induced Lung Injury by Hyperosmolar Sucrose in Rats. Am J Respir Crit Care Med. 172:1002-7.

Paik D.C., Fu, C., Bhattacharya, J., and Tilson, M.D. 2004. Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm. Exp Mol Med. 36:524-33.

Boitano, S., Safdar, Z., Welsh, D.G., Bhattacharya, J., and Koval, M. 2004. Related Articles, Links Cell-cell interactions in regulating lung function. Am J Physiol Lung Cell Mol Physiol. 287:L455-9. Review.

Ichimura, H., Parthasarathi, K., Quadri, S., Issekutz A.C., and Bhattacharya, J. 2003. Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung capillaries. J. Clin. Invest. 111: 691-699.

Quadri, S., Bhattacharjee, M., Parthasarathi, K., Tanita, T., and Bhattacharya, J. 2003. Endothelial barrier strengthening by activation of focal adhesion kinase. J. Biol. Chem. 278:13342-9.

Safdar, Z., Wang, P., Ichimura, H., Issekutz, A.C., Quadri, S., and Bhattacharya. J. 2003. Hyperosmolarity enhances the lung capillary barrier. J. Clin. Invest. 112:1541-9.

Bhattacharya, S., Sen, N., Yiming, M., Patel, R., Parthasarathy, K., Quadri, S., Issekutz, A., and Bhattacharya, J. 2003. High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium. Am J Respir Cell Mol Biol. 28:218-24.

Parthasarathi, K., Ichimura, H., Quadri, S., Issekutz, A., and Bhattacharya, J. 2002. Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries. J. Immunol. 169:7078-7086.


Recent Honors

The Irene and Arthur Fishberg Prize for significant contributions to internal medicine, Columbia University.


Major Grants

Pending NHLBI, RO1HL122730-A1 (PI). Scored in 1st percentile. Proposed Project start date: 09/01/2014 Mitochondrial role in acute lung injury