F A C U L T Y   P R O F I L E 

photon image

Professor of Physiology & Cellular Biophysics and Medicine

Endothelial mechanisms of lung injury using cultured cells and the optically imaged lung.

Office: Black Building| 8th Floor| Room 812
Telephone: 212.305.7093
Fax: 212.305.6701

Current Research

The Lung Biology Laboratory specializes in single and two-photon laser scanning microscopy of the intact lung. The overall direction is to apply real-time imaging in understanding molecular mechanisms underlying lung injury. Ongoing projects are:

• Mitochondrial regulation of lung immunity
• Immune interactions of alveolar macrophages in situ
• Lung mechanobiology of the actin fence
• Platelet-neutrophil interactions in immunity
• Protein transduction in therapy for lung injury

Selected Publications

Rogers RS, J Bhattacharya. When cells become organelle donors. Physiology. 2013 (In press).

Looney MR, J Bhattacharya. Live imaging of the lung. Annu. Rev. Physiol. 2013 (In press).

Huertas, A., Das, S., Emin M., Rifkind JM, J. Bhattacharya and S. Bhattacharya. Erythrocytes induce proinflammatory endothelial activation in hypoxia. Am J Respir Cell Mol Biol. 2013; 48:78-86. PMID:23043086.

Bhattacharya J, Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013;75:593-615. PMID: 23398155.

Quadri S, Sun L, Islam MN, Shapiro L, Bhattacharya J. Cadherin selectivity filter regulates endothelial sieving properties. Nat Commun. 2012;3:1099. PMID:23033075.

Emin, Memet T, Li Sun, A Huertas, S Das, J Bhattacharya, S Bhattacharya. Platelets induce endothelial tissue factor expression in a mouse model of acid-induced lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 2012 Jun 1;302(11):L1209-20. PMID:22505671.

Kristin Westphalen, Eiji Monma, Mohammad N. Islam & Jahar Bhattacharya. Acid contact in the rodent pulmonary alveolus causes proinflammatory signaling by membrane pore formation. Am. J. Physiol. Lung Cell Mol. Physiol. 2012. 303:L107-16. PMID:22561462.

Islam MN, S Das, MT Emin, M Wei, L Sun, K Westphalen, D Rowlands, S Quadri, S Bhattacharya, J Bhattacharya. Mitochondrial transfer from bone marrow-derived mesenchymal stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012. 18:759-765. PMID:22504485.

Bhattacharya, J. 2012. Lung capillaries raise the hypoxia alarm. J Clin Invest. 2012 Nov 1;122(11):3845-7. PMID: 21191375.

Rowlands DJ, MN Islam, S Das, A Huertas, S Quadri, K Horiuchi, N. Inamdar, MT Emin, J Lindert, VS Ten, S Bhattacharya, J Bhattacharya. Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels. J. Clin. Invest. 2011. 121:1986-99. PMID: 21519143.

Perlman, CE, DJ Lederer and J. Bhattacharya. Micromechanics of alveolar edema. Am. J. Resp. Cell. Mol. Biol. 2011. 44:34-9. PMID: 20118224.

Bhattacharya, J. 2010. Seeing is believing. N&V Nature Meth. 8:57-58. PMID: 21191375.

Bhattacharya J, Perlman CE. Commentaries on Viewpoint: Standards for quantitative assessment of lung structure. Air space connectivity. J Appl Physiol. 2010. 109:935-6; PMID: 20848692.

Kiefmann, R., Rifkind, J.M., Nagababu, E., and Bhattacharya, J. 2008. RBC induce hypoxic lung inflammation. Blood. (In press)

Bhattacharya, J. 2008. Lung neovascularization: a tale of two circulations. Am J Physiol Lung Cell Mol Physiol. (Epub)

Quadri, S., and Bhattacharya, J. 2007. Resealing of endothelial junctions by focal adhesion kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 292:L334-42.

Lindert, J., Parthasarathi, K., and Bhattacharya, J. 2007. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am. J. Resp. Cell. Mol. Biol. 36:688-96.

Perlman, C.E., and Bhattacharya, J. 2007. Alveolar micromechanics determined by optical sectioning microscopy. J. Appl. Physiol. 103:1037-44.

Bertuglia, S., Ichimura, H., Fossati, G., Parthasarathi K., Leoni, F., Modena, D., Cremonesi, P., Bhattacharya, J., and Mascagni, P. 2007. ITF1697, a stable Lys-Pro–containing peptide, inhibits Weibel Palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 13:615-24.

Kuebler, W.M., Parthasarathi, K., Lindert, J., and Bhattacharya, J. 2007. Real-time lung microscopy. J Appl Physiol. 102:1255-64.

Bhattacharya, J. 2007. Interpreting the lung microvascular filtration coefficient. Am J Physiol Lung Cell Mol Physiol. 79:357-66

Chatterjee, S., Baeter, S., and Bhattacharya, J. 2007. Endothelial and epithelial signaling in the lung. Am J Physiol Lung Cell Mol Physiol, 293: L517-19.

Ichimura, H., Parthasarathi, K., Issekutz, AC., and Bhattacharya, J. 2005. Pressure-induced leukocyte margination in lung postcapillary venules. Am J Physiol Lung Cell Mol Physiol. 289:L407-12.

Safdar, Z., Yiming, M., Grunig, G., and Bhattacharya, J. 2005. Inhibition of Acid-induced Lung Injury by Hyperosmolar Sucrose in Rats. Am J Respir Crit Care Med. 172:1002-7.

Paik D.C., Fu, C., Bhattacharya, J., and Tilson, M.D. 2004. Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm. Exp Mol Med. 36:524-33.

Boitano, S., Safdar, Z., Welsh, D.G., Bhattacharya, J., and Koval, M. 2004. Related Articles, Links Cell-cell interactions in regulating lung function. Am J Physiol Lung Cell Mol Physiol. 287:L455-9. Review.

Ichimura, H., Parthasarathi, K., Quadri, S., Issekutz A.C., and Bhattacharya, J. 2003. Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung capillaries. J. Clin. Invest. 111: 691-699.

Quadri, S., Bhattacharjee, M., Parthasarathi, K., Tanita, T., and Bhattacharya, J. 2003. Endothelial barrier strengthening by activation of focal adhesion kinase. J. Biol. Chem. 278:13342-9.

Safdar, Z., Wang, P., Ichimura, H., Issekutz, A.C., Quadri, S., and Bhattacharya. J. 2003. Hyperosmolarity enhances the lung capillary barrier. J. Clin. Invest. 112:1541-9.

Bhattacharya, S., Sen, N., Yiming, M., Patel, R., Parthasarathy, K., Quadri, S., Issekutz, A., and Bhattacharya, J. 2003. High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium. Am J Respir Cell Mol Biol. 28:218-24.

Parthasarathi, K., Ichimura, H., Quadri, S., Issekutz, A., and Bhattacharya, J. 2002. Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries. J. Immunol. 169:7078-7086.