ROTHMAN, JAMES, Ph.D. Professor of Physiology & Cellular Biophysics Adjunct Professor, Department of Physiology and Cellular Biophysics Columbia University Chairman Department of Cell Biology Wallace Professor of the Biomedical Sciences, and Professor of Chemistry Yale University More Info >>

Current Research

(See Rothman Lab; and Columbia Genome Center)

1) ELUCIDATING THE UNDERLYING MECHANISMS OF TRANSPORT WITHIN CELLS

2) HIGH THROUGHPUT CELL BIOLOGY

Selected Publications

Yamamoto, A. et al. 2006. Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J. Cell Biol. 172, 719-31.

Antinozzi, P.A. et al. 2006. Functional mapping of disease susceptibility loci using cell biology. PNAS 103, 3698-703.

Giraudo, C.G. 2006. et al. A clamping mechanism involved in SNARE-dependent exocytosis. Science 313, 676-80.

Becker, T., Volchuk, A., Rothman, J.E. 2005. Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc Natl Acad Sci U S A 102, 4022-6.

Cosson, P. et al. 2005. Dynamic transport of SNARE proteins in the Golgi apparatus. Proc Natl Acad Sci U S A 102, 14647-52.

Paumet, F., Rahimian, V., Di Liberto, M., and Rothman, J.E. 2005. Concerted auto-regulation in yeast endosomal t-SNAREs. J Biol Chem 280, 21137-43.

Giraudo, C.G. et al. 2005. SNAREs can promote complete fusion and hemifusion as alternative outcomes. J. Cell Biol. 170, 249-60.

Fix, M. et al. 2004. Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A 101, 7311-6.

Fukasawa, M., Varlamov, O., Eng, W.S., Sollner, T.H., 2004. Rothman, J.E. Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Proc Natl Acad Sci U S A 101, 4815-20.

Paumet, F., Rahimian, V., and Rothman, J.E. 2004. The specificity of SNARE-dependent fusion is encoded in the SNARE motif. Proc Natl Acad Sci U S A 101, 3376-80.

Varlamov, O. et al. 2004. i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion. J Cell Biol 164, 79-88.

Volchuk, A. et al. 2004. Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell 15, 1506-18.

Hu, C. et al. 2003. Fusion of cells by flipped SNAREs. Science 300, 1745-9.