D'ARMIENTO, JEANINE, M.D., Ph.D. Associate Professor of Medicine in Anesthesiology Director of the Center for Molecular Pulmonary Disease in Anesthesiology and Physiology and Cellular Biophysics - Director, Center for LAM and Rare Lung Disease The role of matrix metalloproteases in disease and the inhibition of these enzymes as potential therapy in destructive lung diseases. Email:jmd12@columbia.edu LAMlab

Research Activities

Jeanine M. D’Armiento is a Professor of Medicine in Anesthesiology at Columbia University. Dr. D’Armiento is Director of the Center for Molecular Pulmonary Disease in Anesthesiology and Physiology and Cellular Biophysics, and Director of the Center for Lymphangiomyomatosis (LAM) and Rare Lung Disease. Dr. D’Armiento’s research focuses on understanding the mechanisms of lung injury and repair. Her laboratory integrates both in vitro and in vivo approaches and is uniquely situated to characterize the molecular changes in the study of lung injury and disease so as to identify potential therapeutic targets. Dr. D’Armiento’s clinical work focuses on Rare Disease, and she is the Director of the Center for LAM and Rare Lung Diseases at Columbia University, which serves one of the largest populations of women with LAM in addition to patients with Alpha-1 Antitrypsin deficiency. She presently serves on the Executive Board of the Alpha-1 Foundation and as a Consultant to the Director of the Office of Rare Disease, NCATs. In addition, Dr. D’Armiento serves on the Executive committee of the Columbia University senate and Chairs the Commission on the Status of Women at the University.

Selected Publications

1. D'Armiento J, Dalal SS, Okada Y, Berg RA, Chada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell. 1992;71(6):955-61.

2. Imai K, Dalal SS, Chen ES, Downey R, Schulman LL, Ginsburg M, D'Armiento J. Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema. American journal of respiratory and critical care medicine. 2001;163(3 Pt 1):786-91

3. Mercer BA, Kolesnikova N, Sonett J, D'Armiento J. Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. J Biol Chem. 2004;279(17):17690-6

4. Foronjy RF, Mirochnitchenko O, Propokenko O, Lemaitre V, Jia Y, Inouye M, Okada Y, D'Armiento JM. Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. American Journal of Respiratory and Critical Care Medicine. 2006;173(6):623-31

5. Foronjy R, Imai K, Shiomi T, Mercer B, Sklepkiewicz P, Thankachen J, Bodine P, D'Armiento J. The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol. 2010;177(2):598-607. PMCID: 2913334

6. Geraghty P, Dabo AJ, D'Armiento J. TLR-4 contributes to cigarette smoke (CS) induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J Biol Chem. 2011

7. Lemaitre V, Dabo AJ, D'Armiento J. Cigarette smoke components induce matrix metalloproteinase-1 in aortic endothelial cells through inhibition of mTOR signaling. Toxicol Sci. 2011;123(2):542-9. PMCID: 3179676

8. Goldklang M, Golovatch P, Zelonina T, Trischler J, Rabinowitz D, Lemaitre V, D'Armiento J. Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice. American Journal Of Physiology Lung Cellular And Molecular Physiology. 2012;302(11):L1200-8. PMCID: 3379042

9. Shiomi T, Sklepkiewicz P, Bodine PV, D'Armiento JM. Maintenance of the bronchial alveolar stem cells in an undifferentiated state by secreted frizzled-related protein 1. Faseb J 2014;28:5242-9.

10. Carver PI, Anguiano V, D'Armiento JM, Shiomi T. Mmp1a and Mmp1b are not functional orthologs to human MMP1 in cigarette smoke induced lung disease. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2015;67:153-9.

11. Woode D, Shiomi T, D'Armiento J. Collagenolytic matrix metalloproteinases in chronic obstructive lung disease and cancer. Cancers (Basel) 2015;7:329-41.

12. Sklepkiewicz P, Shiomi T, Kaur R, Sun J, Kwon S, Mercer B, Bodine P, Schermuly RT, George I, Schulze PC, D'Armiento JM. Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy. Circulation Heart failure 2015;8:362-72.

14. Al Shammari B, Shiomi T, Tezera L, Bielecka MK, Workman V, Sathyamoorthy T, Mauri F, Jayasinghe SN, Robertson BD, D'Armiento J, Friedland JS, Elkington PT. The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis. J Infect Dis 2015;212:463-73.

15. Pollack D, Xiao Y, Shrivasatava V, Levy A, Andrusier M, D'Armiento J, Holz MK, Vigodner M. CDK14 expression is down-regulated by cigarette smoke in vivo and in vitro. Toxicol Lett 2015;234:120-30.

16. Trischler J, Shiomi T, Turner DL, Sklepkiewicz PL, Goldklang MP, Tanaka KF, Xu M, Farber DL, D'Armiento JM. Immune Modulation of the T Cell Response in Asthma through Wnt10b. Am J Respir Cell Mol Biol 2016;54:584-93.

17. Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini D, Sweeney HL, D’Armiento J, Ali ZA, Schulze PC, George I. Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 2015;309:H459-70.

18. Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabon MA, Konrad C, Polverino F, Siempos, II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med 2016.

20. D'Armiento J, Shiomi T, Marks S, Geraghty P, Sankarasharma D, Chada K. Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation. Cancer Res 2016;76:844-54.

21.Xiao R, Goldklang MP, D'Armiento JM. Parenchymal Airspace Profiling: Sensitive Quantification and Characterization of Lung Structure Evaluating Parenchymal Destruction. Am J Respir Cell Mol Biol 2016;55:708-15.

22.Goldklang MP, Tekabe Y, Zelonina T, Trischler J, Xiao R, Stearns K, Romanov A, Muzio V, Shiomi T, Johnson LL, D'Armiento JM. Single-Photon Emission Computed Tomography/Computed Tomography Imaging in a Rabbit Model of Emphysema Reveals Ongoing Apoptosis In Vivo. Am J Respir Cell Mol Biol 2016;55:848-57.

23. McCormack FX, Gupta N, Finlay GR, Young LR, Taveira-DaSilva AM, Glasgow CG, Steagall WK, Johnson SR, Sahn SA, Ryu JH, Strange C, Seyama K, Sullivan EJ, Kotloff RM, Downey GP, Chapman JT, Han MK, D'Armiento JM, Inoue Y, Henske EP, Bissler JJ, Colby TV, Kinder BW, Wikenheiser-Brokamp KA, Brown KK, Cordier JF, Meyer C, Cottin V, Brozek JL, Smith K, Wilson KC, Moss J, Lymphangioleiomyomatosis AJCo. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. Am J Respir Crit Care Med 2016;194:748-61.

24. Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW. Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. J Clin Invest 2016;126:3063-79.

25. Geraghty P, Baumlin N, Salathe MA, Foronjy RF, D'Armiento JM. Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. Mediators Inflamm 2016;2016:9461289.

26. Toba H, Cannon PL, Yabluchanskiy A, Iyer RP, D'Armiento J, Lindsey ML. Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis. Am J Physiol Heart Circ Physiol 2017;312:H375-H83.

27. Unachukwu U, Trischler J, Goldklang M, Xiao R, D'Armiento J. Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs. Faseb J 2017;31(6):2340-2351.

28. Turner, D.L., Goldkang, M.P., Trischler, J., Cvetkovski, F., D’Armiento, J.M., and Farber, D.L. Generation and in situ activation of lung tissue-resident memory CD4 T cells in the pathogenesis of allergic asthma. (2018) In Press J. Immunology.

29. Mazumder, S., Lee, A., Dube, B., Teneja, S., Mehra, D., Yan, B., Chillrud, S., Bhandari, N., and D’Armiento, J. Respiratory health and effects of biomass smoke exposure. (2018). Scientific Reports Under Revision.

30. Sonett, J., Goldklang, M., Sklepkiewicz, P., Gerber, A., Trishler, J., Zelonina, T., Westerterp, M., Lemaitre, V., Okada, Y., and D’Armiento, J. A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure (2018) In Press, Faseb J.