F A C U L T Y P R O F I L E
GOGOS, JOSEPH A., M.D., Ph.D.
Genetics and Animal Models of Complex Psychiatric Disorders; assembly and maintenance of sensory maps in the brain.
Office: Physicians & Surgeons | 11th floor | Room 519
The goal of our research is to understand the nature of the genetic deficits that predispose to psychiatric disorders (primarily schizophrenia) and trace the affected neural pathways. Ultimately, we would like to provide novel targets for pharmacotherapy for these disorders. Toward these goals, my lab has two interconnected research programs:
i. Genetics of Complex Psychiatric Disorders: Most psychiatric disorders have a strong genetic component and, therefore, our starting point is findings from human genetic approaches. Our genetics program has contributed a series of genetic discoveries especially on the contribution of rare mutations in the genetic architecture of complex psychiatric disorders.
ii. Animal Models of Complex Psychiatric Disorders: We are using mouse models of disease-predisposing mutations to ask what are the consequences of a genetic lesion associated with mental illness in humans, on brain structure and function of a model organism, starting at the simpler cellular and synaptic levels to the higher-order circuit and behavior levels. Implementation of a range of state-of-the-art approaches to dissect the genetic and biological complexity of psychiatric disorders is the major component of my lab and has contributed a series of recent discoveries.
Xu B, Hsu PK, Stark KL, Karayiorgou M, Gogos JA. 2013 Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion Cell 152(1-2):262-75.
Fénelon K, Xu B, Lai CS, Mukai J, Markx S, Stark KL, Hsu PK, Gan WB, Fischbach GD, Macdermott AB, Karayiorgou M, Gogos JA. 2013 The Pattern of Cortical Dysfunction in a Mouse Model of a Schizophrenia-Related Microdeletion. J Neurosci. 33(37):14825-14839.
Xu B, Ionita-Laza I, Roos JL, Boone B, Woodrick S, Sun Y, Levy S, Gogos JA, Karayiorgou M. 2012 De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia. Nat Genet. 44(12):1365-9.
Kvajo M, McKellar H, Drew LJ, Lepagnol-Bestel AM, Xiao L, Levy RJ, Blazeski R, Arguello PA, Lacefield CO, Mason CA, Simonneau M, O'Donnell JM, MacDermott AB, Karayiorgou M, Gogos JA. 2011 Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.Proc Natl Acad Sci U S A. 108(49):E1349-58.
Sigurdsson T, Stark KL, Karayiorgou M, Gogos JA, Gordon JA. 2010 Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature 464:763-7.
Mukai J, Dhilla A, Drew LJ, Stark KL, Cao L, Macdermott AB, Karayiorgou M, Gogos JA. 2008 Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nat Neurosci. 11:1302-10.
Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M. 2008. Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet. 40:880-5.
Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills AA, Karayiorgou M, Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet. 40:751-60.
Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, Gogos JA. 2005. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci. 8:1586-94
Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. 2004. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet. 36:131-7.