F A C U L T Y   P R O F I L E 

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ABBOTT, LAURENCE F. PH.D.
Professor of Physiology & Cellular Biophysics

Mathematical modeling and analysis of neurons and neural networks.

Office: Kolb Research Annex| 7th floor | Room 759
Telephone: 212.543.5070
Fax: 212.543.5010
Email:
lfa2103@columbia.edu

Current Research

My research involves the mathematical modeling and analysis of neurons and neural networks. Analytic techniques and computer simulation are used to study how different conductances contribute to the electrical characteristics of a neuron, how neurons interact to produce functioning neural circuits, and how large populations of neurons represent, store, and process information.

Selected Publications

Kato, S., Xu, Y., Cho, C., Abbott, L.F. and Bargmann, C. (2014) Temporal Responses of C. Elegans Chemosensory Neurons are Matched to Behavior. Neuron 81:616-628.

Kennedy, A., Wayne, G., Kaifosh, P., Alvina, K., Abbott, L.F. and Sawtell, N.B. (2014) A Temporal Basis for Predicting the Sensory Consequences of Motor Commands in an Electric Fish. Nature Neurosci. 17:416-424.

Fink, A.J.P., Croce, K.R., Huang, Z.J., Abbott, L.F., Jessell, T.M. and Azim, E. (2014) Presynaptic Inhibition of Spinal Sensory Feedback Ensures Smooth Movement. Nature 509:43-48.

Le Masson, G., Przedborski, S. and Abbott, L.F. (2014) A Computational Model of Motor Neuron Degeneration. Neuron 83:975-988.

Wayne, G. and Abbott, L.F. (2014) A Design Procedure for Hierarchical Network Control. Neural Comp. 24:1-31.

Stern, M., Sompolinsky, H. and Abbott, L.F. (2014) Dynamics of Random Neural Networks with Bistable Units. (submitted).

Aso, Y., Hattori, D., Yu, Y., Johnston, R.M., Iyer, N., Ngo, T.B., Dionne, H., Abbott, L.F., Axel, R., Tanimoto, H. and Rubin,(2014) The Neuronal Architecture of the Mushroom Body Provides a Logic for Associative Learning. (submitted).

Schaffer, E.S., Ostojic, S. and Abbott L.F. (2013) A Complex-Valued Firing-Rate Model that Approximates the Dynamics of Spiking Networks. PLoS Comput. Biol. 9:e1003301.

Caron, S.J.C, Ruta, V., Abbott, L.F. and Axel, R. (2013) Random Convergence of Afferent Olfactory Inputs in the Drosophila Mushroom Body. Nature 497:113-117.

Barak, O., Sussillo, D., Romo, R., Tsodyks, M. and Abbott, L.F. (2013) From Fixed Points to Chaos: Three Models of Delayed Discrimination. Prog. in Neurobiol. 103:214-222.

Babadi, B. and Abbott, L.F. (2013) Pairwise Analysis Can Account for Network Structures Arising from Spike-Timing Dependent Plasticity. PLoS Comput. Biol. 9:e1002906.

White, B., Abbott, L.F. and Fiser, J. (2012) Suppression of cortical neural variability is stimulus- and state-dependent. J. Neurophysiol. 108:2383-2392.

Sussillo, D. and Abbott, L.F. (2012) Transferring Learning from External to Internal Weights in Echo-State Networks with Sparse Connectivity. PLoS One 7:e37372.

Toyoizumi, T. and Abbott, L.F. (2011) Beyond the Edge of Chaos: Amplification and Temporal Integration by Recurrent Networks in the Chaotic Regime. Phys. Rev E 84:051908.

Monaco, J.D. and Abbott, L.F. (2011) Modular Realignment of Entorhinal Grid Cell Activity as a Basis for Hippocampal Remapping. J. Neurosci. 31:9414-9425.

Babadi, B. and Abbott, L.F. (2010) Intrinsic Stability of Temporally Shifted Spike-Timing Dependent Plasticity. PLoS Comput. Biol. 6:e1000961.

Chalasani, S., Kato, S., Albrecht, D., Nakagawa, T., Abbott, L.F. and Bargmann, C. (2010) Neuropeptide Feedback Modifies Odor-Evoked Dynamics in C. Elegans Olfactory Neurons. Nature Neurosci. 13:615-621.

Luo, S., Axel, R. and Abbott, L.F. (2010) Generating Sparse and Selective Third-Order Responses in the Olfactory System of the Fly. Proc. Natl. Acad. Sci. USA 107:10713-10718.

Rajan, K., Abbott, L.F. and Sompolinsky, H. (2010) Stimulus-Dependent Suppression of Chaos in Recurrent Neural Networks. Phys. Rev. E 82:011903.

Sussillo, D. and Abbott, L.F. (2009) Generating Coherent Patterns of Activity from Chaotic Neural Networks. Neuron 63:544-557.

Muzzio, I.A., Levita, L., Kulkarni, J., Monaco, J., Kentros, C., Stead, M., Abbott, L.F. and Kandel, E.R. (2009) Stability of Hippocampal Representations and Neuronal Synchrony are Differentially Modulated by Attention to Spatial and Non-Spatial Contigencies. PLoS Biol. 7:e1000140.

George, M.S., Abbott, L.F. and Siegelbaum, S.A. (2009) Hyperpolarization-Activated HCN Cation Channels Exert Inhibit Subthreshold EPSPs Through Interactions with M-Type K+ Channels. Nature Neurosci. 12:577-584.

Vogels, T.P. and Abbott, L.F. (2009) Gating Multiple Signals through Detailed Balance of Excitation and Inhibition in Spiking Networks. Nature Neurosci. 12:483-491

Abbott, L.F. (2008) Theoretical Neuroscience Rising. Neuron 60:489-495.

Abbott, L.F., and Luo, S.X. 2007. A Step Toward Optimal Coding in Olfaction (news and views). Nature Neurosci. 10:1342-1343.

Abbott, L.F, and Rohrkempter, R. 2007. A Simple Growth Model Constructs Critical Avalanche Networks. Prog. Brain Res. 165:13-19.

Rumsey, C., and Abbott, L.F. 2006. Synaptic Democracy in Active Dendrites. J. Neurophys. 96:2307-2318.

Rajan, K., and Abbott, L.F. 2006. Eigenvalue Spectra of Random Matrices for Neural Networks. Phys. Rev. Lett. 97:188104.

Swinehard, C., and Abbott, L.F. 2006. Dimensional Reduction in Reward- Based Learning. Network: Comp. Neural Sys. 17:235-252.

Billimoria, C.P., DiCaprio, R.A., Birmingham, J.T., Abbott, L.F. and Marder, E. 2006. Neuromodulation of spike timing precision in sensory neurons. J. Neurosci. 26:5910-5919.

Drew, P.J. and Abbott, L.F. 2006. Extending the Effects of STDP to Behavioral Timescales. Proc. Natl. Acad. Sci. USA 103:8876-8881.

Drew, P.J. and Abbott, L.F. 2006. Models and Properties of Power-Law Adaptation in Neural Systems. J. Neurophysiol. 96:826-833.

Rumsey, C. and Abbott, L.F. 2006. Synaptic Democracy in Active Dendrites. J. Neurophys. doi:10.1152/jn.00149.

Swinehard, C. and Abbott, L.F. 2006. Dimensional Reduction in Reward-Based Learning. Network: Comp. Neural Sys. (3):235-52.

Swinehart, C., and Abbott, L.F. 2005. Supervised Learning Through Neuronal Response Modulation. Neural Computation 17:609-631.

Fusi, S., Drew, P., and Abbott, L.F. 2005. Cascade Models of Synaptically Stored Memories. Neuron 45:599-611.

Vogels, T.P., Rajan, K., and Abbott, L.F. 2005. Neural Network Dynamics. Annu. Rev. Neurosci. 28:357-376.

Vogels, T.P. and Abbott, L.F. 2005. Signal Propagation in Networks of Integrate-and-Fire Neurons. J. Neurosci.

Rumsey, C., and Abbott, L.F. 2004. Equalization of Synaptic Efficacy by Activity - and Timing-Dependent Synaptic Plasticity. J. Neurophysiol. 91:2273-2280.

Prinz, A.A., Abbott, L.F., and Marder, E. 2004. The Dynamic Clamp Comes of Age. Trends in Neurosci 27:218-224.

Abbott, L.F., and Regehr, W. 2004. Synaptic Computation. Nature 431:796-803.

 

Awards and Honors

2010 Swartz Prize for Theoretical and Computational Neuroscience

2013 Mathematical Neuroscience Prize

2014 National Academy of Sciences

 

Major Grants

2014-2019 Advanced Graduate Training Program in Theoretical Neuroscience, PI, National Institute of Neurological Disorders and Stroke

2014-2016 Random Circuits and Representations within Structured Brain and Spinal Cord Regions Support Flexible Behaviors, Co-PI, Mathers Foundation

2014-2019 Gatsby Initiative in Brain Circuitry, Co-PI,Gatsby Foundation

2014-2017 Modeling Higher-Level Olfactory Circuits, PI , Simons Foundation

2014-2017 From sensation to perception: cellular and circuit mechanisms underlying prey detection in an electric fish, Co-PI, $720,000, NSF CRCNS